Get your flu shot, please.

We are in the midst of the CDC’s National Influenza Vaccination Week, December 6-12, 2015. It’s still critically important that anyone who is able get their flu shot as soon as possible. Not only are you protecting yourself, you are also protecting the vulnerable people around you.

While death from the flu is thankfully rare, it does happen. One mother who knows this all too well is Rebecca Hendricks. Her beautiful daughter, Scarlet Anne, was one of 147 children in the US who died of the flu during the 2014-2015 flu season. I urge you to read their story at Shot of Prevention.

One reason why some pregnant women fear getting a flu shot is that they worry it can cause miscarriage and stillbirth. Thankfully, there is no evidence that the shot can harm an unborn child, and plenty of evidence that the shot can help protect mom and baby from the flu.

As a loss mom, I can somewhat understand the pain that Rebecca is going through, and I can understand the worry that causes some moms to forgo the flu shot. My first daughter, Ada MaryJo, was stillborn in 2013. While we suspect a car accident was at least part of the cause, we never got a firm diagnosis. In up to 50% of all stillbirths where an autopsy is performed, the cause is never discovered. Even a higher number of miscarriages are unexplained.

Now that obstetricians are recommending that every pregnant woman get the flu shot (along with the CDC, Mayo Clinic, and others), it’s easy to think “I got the flu shot and lost the baby”. While I can totally understand that thought, there’s a lot of things that we all do that certainly don’t cause miscarriage or stillbirth even though there’s a high correlation. For example, most women eat saltines and drink ginger ale while pregnant, so most of us that experience miscarriage or stillbirth had eaten saltines and drank ginger ale. Of course that doesn’t mean our loss was caused by those things!

To make things more confusing, very few medicines or vaccines are tested directly on pregnant women or babies. It’s a difficult debate (Lancet, Healthline) where the need for information comes up against the need to protect developing babies. Thankfully there are more and more studies of the flu vaccine in pregnant women all the time, but they are more rare than studies in non-pregnant adults. So, many vaccines are indeed untested in pregnant women.

Vaccines often end up in pregnancy drug category B or C because the only safety evidence is from studies in pregnant animals. What does this mean? If a vaccine is in category B or C it means we just don’t have enough information. This does not mean there’s evidence it’s unsafe (that’s category D or X). Thankfully, scientists have followed up with studies of pregnant women.

A recent example of a huge study is Risk of Fetal Death after Pandemic Influenza Virus Infection or Vaccination, published in January of 2013. The researchers (funded by the Norwegian Institute of Public Health and the US National Institutes of Health) looked at 117,347 pregnancies in Norway from 2009-2010. Of all these pregnancies, 570 babies were miscarried or stillborn (4.9 deaths per 1000 births). For comparison, the US has 6.25 stillbirths per 1000 plus many more miscarriages.

Among women got the flu vaccine, women who had the flu during pregnancy were more likely to lose the baby compared to women who did not have the flu. Among women who did not get the flu, women who had the vaccine were less likely to lose the baby than women who were not vaccinated. Today Health has a nice summary of this study: Flu vaccine safe in pregnancy, study confirms.

Another way to look at potential problems with vaccines is to look for any potential adverse reactions that could be related to taking a medication. The CDC collects such data in the Vaccine Adverse Event Reporting System (VAERS). Adverse events reported in pregnant women were described in the study Adverse events in pregnant women following administration of trivalent inactivated influenza vaccine and live attenuated influenza vaccine in the Vaccine Adverse Event Reporting System, 1990-2009.

Between 1990 and 2009, there were only 20 miscarriages or stillbirths reported by pregnant women who had taken either inactivated or live attenuated flu vaccines. This means there were just 1.9 miscarriages or stillbirths per million pregnant women vaccinated (again, for comparison, the US has 6.25 stillbirths per 1000 plus many, many more miscarriages).

Between these two huge studies, it’s clear that the flu vaccine has a protective effect, with far fewer miscarriages and stillbirths in women who are vaccinated than in women who are not.

Of course, these aren’t the only studies that found the flu vaccine to be safe – you can find a ton more at PubMed. One great thing is that More types of flu shots available than ever so we can pick and choose the ones that we feel most comfortable with, based on the latest research.

Author’s note: A version of this post originally appeared at Remembering Ada. This updated article has been posted at Science Moms.


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